ND-630
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 10mg | Ikhona evenkileni | 300 |
| 50mg | Ikhona evenkileni | 500 |
| 100mg | Ikhona evenkileni | 800 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide
Ikhowudi yoncumo:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
Ikhowudi ye-InChi:
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
Isitshixo se-InChi:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
Igama elingundoqo:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-ND-630 inqanda i-hACC1 (IC50=2.1±0.2 nM) kunye ne-hACC2 (IC50=6.1±0.8 nM). Isithintelo siyabuyiselwa umva kwaye sichane kakhulu kwi-ACC. I-ND-630 inqanda umsebenzi we-ACC ngokusebenzisana ngaphakathi kwe-phosphopeptide-acceptor kunye ne-dimerization site ye-enzyme ukukhusela i-dimerization. I-ND-630 inqanda i-fatty acid synthesis kunye ne-EC50 ye-66 nM kwiiseli ze-HepG2 ngaphandle kokuguqula inani elipheleleyo leeseli, ukugxilwa kweprotheni yeselula, kunye nokufakwa kwe-acetate kwi-cholesterol[1].
Ithagethi: ACC
