STING agonist-4
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Pangalan ng Kemikal:
1,1'-(butane-1,4-diyl)bis(2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazole-5-carboxamide)
SMILES Code:
O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC (C)=NN6CC)=O)=NC2=C1)N
InChi Code:
InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23- 17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)4 8)18-24(26)38-34(44)40-32(50)28-16-20(4)42-46(28)6-2/h9-12,15-18 H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50)
InChi Key:
ICZSAXDKFXTSGL-UHFFFAOYSA-N
Keyword:
Solubility:
Imbakan:
Paglalarawan:
Ang STING agonist-4 ay isang stimulator ng Interferon Genes (STING) receptor agonist na may maliwanag na inhibitory constant (IC50) na 20 nM. Ang STING agonist-4 ay isang compound na nakabatay sa amidobenzimidazole (ABZI) na may kaugnayan sa symmetry upang lumikha ng mga naka-link na ABZI (diABZIs) na may pinahusay na pagbubuklod sa STING at cellular function
Target: STING
