Sildenafil Citrate

Jina la Kemikali:

5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin- 7-moja 2-hydroxypropane-1,2,3-tricarboxylate

Msimbo wa SMILES:

"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O )C(CC(=O)O)(C(=O)O)O"

Msimbo wa InChi:

InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9- 18(16)32-6-2)33(30,31)28-12-10- 26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10 -13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

Ufunguo wa InChi:

DEIYFTQMQPDXOT-UHFFFAOYSA-N

Neno muhimu:

Sildenafil Citrate;UK 92480-10;UK-92,480-10; Revatio; VIAGRA;171599-83-0;CAS:171599-83-0;CAS:171599-83-0

Umumunyifu:Mumunyifu katika DMSO

Hifadhi:0 - 4°C kwa muda mfupi (siku hadi wiki), au -20°C kwa muda mrefu (miezi)

Maelezo:

Sildenafil, Citrate ni aina ya citrate ya Sildenafil. Sildenafil ni kizuia teule cha PDE5 (aina 5 cGMP phosphodiesterase) ambayo huchochea hidrolisisi ya 3',5'-cyclic guanosine monophosphate (cGMP). Kama kizuizi cha PDE5, Sildenafil imeripotiwa kuimarisha neuro-, sinepto- na angiogenesis katika mifano ya panya ya kiharusi na pia inaripotiwa kuwa vasodilata kidogo. Sildenafil pia imeonyeshwa kuzuia uundaji wa vidonda vya utumbo mdogo unaosababishwa na indomethacin kupitia utaratibu unaotegemea NO/cGMP.

Lengo: PDE5