BLU-667

Jina la Kemikali:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

Msimbo wa SMILES:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

Msimbo wa InChi:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5-7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13- 16,19,21H,9-12H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

Ufunguo wa InChi:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Neno muhimu:

BLU-667; BLU 667; BLU667

Umumunyifu:DMSO

Hifadhi: 

Maelezo:

BLU-667 ni kizuizi chenye nguvu na cha kuchagua cha mabadiliko ya RET, miunganisho, na vibadilika vilivyotabiriwa sugu. Muunganisho wa RET ni vichochezi muhimu vya saratani nyingi, ikijumuisha saratani ya mapafu na tezi, na utafiti wetu unapendekeza kuwa RET pia ina jukumu muhimu katika saratani ya koloni na matiti. Kwa kulenga wakati huo huo kiendeshaji msingi na vibadilikaji vilivyotabiriwa vinavyokinza ambavyo hufanya seli za saratani kutojali matibabu na dawa zilizoidhinishwa kwa sasa,

Lengo: RET