BI-847325
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 400 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 950 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1400 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
SMILES Khouto:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
Khoutu ea InChi:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2, 1-3H3,(H,30,34)(H,32,35)/b28-27-
InChi Key:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Keyword:
BI-847325, BI847325, BI 847325, 1207293-36-4
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)
Tlhaloso:
BI-847325 ke mefuta e 'meli e khethiloeng ea MEK/Aurora kinase inhibitor e nang le litekanyetso tsa IC50 tsa 3, 25, 15, 25, le 4 nM bakeng sa X. laevis Aurora B, Aurora A ea motho le Aurora C, le MEK1 ea motho le MEK2 ka ho latellana. E ka thibela kholo le ho phela ha melanoma e sa tsebeng kalafo le e hananang le lithethefatsi, ea fokotsa polelo ea MEK le Mcl-1 ha e ntse e eketsa polelo ea pro-apoptotic protein Bim. Ka 70 mg/kg, BI-847325 e kenya apoptosis ho melanoma e sa tsebeng ho phekola le e hananang le lithethefatsi ka har'a vivo.
Sepheo: MEK/Aurora
