BLU-667

Lebitso la lik'hemik'hale:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

SMILES Khouto:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

Khoutu ea InChi:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5-7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13- 16,19,21H,9-12H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

InChi Key:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Keyword:

BLU-667; BLU 667; BLU667

Sollubility:DMSO

Polokelo: 

Tlhaloso:

BLU-667 ke inhibitor e matla le e khethang ea liphetoho tsa RET, fusions, le liphetoho tse boletsoeng esale pele tse hanyetsanang. Li-fusion tsa RET ke tsona tse ka sehloohong tse bakang mofets'e o mongata, ho kenyelletsa le mofets'e oa matšoafo le oa qoqotho, 'me lipatlisiso tsa rona li fana ka maikutlo a hore RET le eona e na le karolo ea bohlokoa ho tse ling tsa mofetše oa mala le oa matsoele. Ka ho shebana le mokhanni oa mantlha le liphetoho tse hanoang esale pele tse etsang hore lisele tsa mofets'e li se utloele kalafo ka litlhare tse amohetsoeng hajoale,

Sepheo: RET