BLU-9931
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 220 |
| 300mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1350 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide
SMILES Khouto:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
Khoutu ea InChi:
InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17 (16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) (H,29,31,32)
InChi Key:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Keyword:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
Liseleng tsa MDA-MB-453, BLU9931 e thibela ka mokhoa o matla phosphorylation ea tsela ea pontšo ea FGFR4. BLU9931 e thibela ho ata ha lisele tsa HCC tse hlalosang mokhoa o tsitsitseng oa FGFR4, joalo ka Hep 3B, HUH-7, le JHH-7 cell line, le EC50 ea<1 μM. BLU9931 e boetse e thibela ho ata ha lisele tse tsoang ho PDX tse nang le tsela e sa fetoheng ea FGFR4 [1]. BLU9931 e etsa hore tumor e fokotsehe mefuteng ea hepatocellular carcinoma e hlalosang mokhoa o sebetsang oa ligand / receptor o nang le FGF19 / FGFR4 / KLB mme e eketsa lenane le ntseng le hōla la li-anti-FGFR4 agents [2].
Sepheo: FGFR4
