Adavivint
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
N-(5-{3-[7-(3-fluorophenyl))-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3 - methylbutanamide
SMILES Khouto:
CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN= C1)=O
Khoutu ea InChi:
InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28( 37-36-24) 29-34 -25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,( H,33,38)(H,34,35)(H,36,37)
InChi Key:
AQDWDWAYVBQMAM-UHFFFAOYSA-N
Keyword:
Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
Novel molek'hule e nyane ea Wnt pathway inhibitor e nang le EC50 ea 3 nM in vitro; e etsa hore ho be le phapang ea hMSC ho li-chondrocyte tse holileng, tse sebetsang hantle le ho fokotsa maemo a matšoao a lefu la lefufuru; e ntlafatsa haholo lintlha tsa histology tsa Osteoarthritis Research Society International (OARSI) le li-biomarker ka mokhoa oa litoeba oa OA.
Sepheo: WNT
