Tropifexor
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1850 |
| 5g | E teng thepeng e teng ka lebenkeleng | 7400 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8- yl) -4-fluorobenzo[d]thiazole-6-carboxylic acid
SMILES Khouto:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C(O)=O)C=C7S6)[C@H](CC5)C4
Khoutu ea InChi:
InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18(11-16)39-13-20-24( 35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14, 16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
InChi Key:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Keyword:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
Tropifexor (motsoako oa 1) ke buka le agonist e matla haholo ea FXR e nang le EC50 ea 0.2 nM. Ho kenngoa ho matla ha liphatsa tsa lefutso tsa BSEP le SHP ho bonoa liseleng tsa mantlha ke Tropifexor ka mokhoa o itšetlehileng ka mahloriso. BSEP induction ka holim'a taolo ea koloi (DMSO) e hlokomeloa maemong a tlaase joaloka 1 nM, ha ho kenngoa ka matla ha SHP (15-fold ka holimo koloi) ho hlokomeloa ho 10 nM le ho kenngoa ka mokhoa o itekanetseng oa SHP ho 1 nM (3-fold) [1 ].
Sepheo: FXR
