SEL120-34A

Magaca Kiimikada:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij] quinoline Hydrochloride

Koodhka dhoola cadeynta:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Koodhka InChi:

InChi=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

Furaha InChi:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Ereyga muhiimka ah:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Xalka: 

Kaydinta: 

Sharaxaad:

SEL120-34A waa xakameyn awood leh oo door ah CDK8 oo firfircoon oo ku jira unugyada AML oo leh heerar sare oo fosforyaalka serine ee STAT1 iyo STAT5 domains transactivation. EL120-34A waxay joojisaa fosforyaalka STAT1 S727 iyo STAT5 S726 ee unugyada kansarka ee vitro. Si joogto ah, sharciyeynta STATs- iyo NUP98-HOXA9-ku-tiirsanaanta qoraalka ayaa loo arkay inay tahay habka ugu muhiimsan ee ficilka gudaha vivo.

Ujeedka: CDK8