MC180295

MC180295
  • Magaca:MC180295
  • Lambarka buugga:CPD100908
  • Lambarka CAS:2237942-08-2
  • Miisaanka Molecular:358.11
  • Foomka Kiimikada:C17H18N4O3S
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    Faahfaahinta Alaabta

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    Magaca Kiimikada:

    Rel-(4-amino-2-((2S)-bicyclo[2.2.1] heptan-2-yl) amino) thiazol-5-yl) (2-nitrophenyl) methanone

    Koodhka dhoola cadeynta:

    O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O

    Koodhka InChi:

    InChi=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8- 9-5-6-10 (12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1

    Furaha InChi:

    JRNXAQINDCOHGS-CBINBANVSA-N

    Ereyga muhiimka ah:

    Xalka: 

    Kaydinta: 

    Sharaxaad:

    MC180295 waa xakameynta CDK9 aad u dooratay (IC50 = 5 nM). (MC180295 waxa uu leeyahay hawlo ballaadhan oo ka hortagga kansarka oo ku jira vitro waxana uu wax ku ool u yahay moodooyinka kansarka vivo. Intaa waxa dheer, xannibaadda CDK9 waxay dareensiisaa isbaarada difaaca ee α-PD-1 in vivo, taasoo ka dhigaysa bartilmaameed aad u fiican daaweynta epigenetic ee kansarka.

    Ujeedka: CDK9


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