MC180295
Faahfaahinta Alaabta
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Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
Magaca Kiimikada:
Rel-(4-amino-2-((2S)-bicyclo[2.2.1] heptan-2-yl) amino) thiazol-5-yl) (2-nitrophenyl) methanone
Koodhka dhoola cadeynta:
O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O
Koodhka InChi:
InChi=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8- 9-5-6-10 (12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1
Furaha InChi:
JRNXAQINDCOHGS-CBINBANVSA-N
Ereyga muhiimka ah:
Xalka:
Kaydinta:
Sharaxaad:
MC180295 waa xakameynta CDK9 aad u dooratay (IC50 = 5 nM). (MC180295 waxa uu leeyahay hawlo ballaadhan oo ka hortagga kansarka oo ku jira vitro waxana uu wax ku ool u yahay moodooyinka kansarka vivo. Intaa waxa dheer, xannibaadda CDK9 waxay dareensiisaa isbaarada difaaca ee α-PD-1 in vivo, taasoo ka dhigaysa bartilmaameed aad u fiican daaweynta epigenetic ee kansarka.
Ujeedka: CDK9