Alvocidib

Magaca Kiimikada:

2- (2-chlorophenyl) -5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-hal

Koodhka dhoola cadeynta:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

Koodhka InChi:

InChi=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28- 21 (19) 20) 11-4-2-3-5-13 (11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12- ,17+/m1/s1

Furaha InChi:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

Ereyga muhiimka ah:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Xalka: 

Kaydinta: 

Sharaxaad:

Alvocidib waa isku-darka N-methylpiperidinyl chlorofenyl flavone-ka. Sida xannibaadaha kinase-ku-tiirsanaanta cyclin-ku-tiirsan, alvocidib wuxuu keenaa xiritaanka wareegga unugyada isagoo ka hortagaya fosforyaalka kinases-ku-tiirsanaanta cyclin (CDKs) iyo hoos-u-habaynta cyclin D1 iyo D3 muujinta, taasoo keentay in la xiro wareegga unugyada G1 iyo apoptosis. Wakiilkani sidoo kale waa horjooge tartan u ah waxqabadka adenosine triphosphate. Hubi tijaabooyin caafimaad oo firfircoon ama tijaabooyin caafimaad oo xidhan adoo isticmaalaya wakiilkan.

Ujeedka: CDK