LDC000067

Magaca Kiimikada:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

Koodhka dhoola cadeynta:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

Koodhka InChi:

InChi=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13( 9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

Furaha InChi:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Ereyga muhiimka ah:

LDC000067; LDC-000067; LDC 000067

Xalka: 

Kaydinta: 

Sharaxaad:

LDC000067 waa horjooge awood leh oo door ah CDK9. LDC000067 waxay joojisay qoraalka faytrooga ee ATP-tartan iyo hab ku-tiirsanaan ah. Muujinta hidda-wadaha unugyada lagu daweeyay LDC000067 waxay muujisay hoos u dhigista xulashada mRNA-yada muddada gaaban, oo ay ku jiraan xeeriyeyaasha muhiimka ah ee faafinta iyo apoptosis. Falanqaynta isku-dhafka de novo RNA waxay soo jeedisay door wanaagsan oo ballaaran oo CDK9 ah. Marka la eego heerka molecular iyo unugga, LDC000067 waxay soo saartay saamaynta lagu garto xannibaadda CDK9 sida joojinta la xoojiyey ee RNA polymerase II ee hiddo-wadaha iyo, tan ugu muhiimsan, soo-gelinta apoptosis ee unugyada kansarka. LDC000067 waxay joojisaa qoraalka ku-tiirsanaanta P-TEFb. Waxay keentaa apoptosis in vitro iyo in vivo oo ay weheliso BI 894999.

Ujeedka: CDK9