Voruciclib

Magaca Kiimikada:

2- (2-Chloro-4- (trifluoromethyl) phenyl) -5,7-dihydroxy-8-((2R,3S) -2- (hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-1-benzopyran -4-hal

Koodhka dhoola cadeynta:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Koodhka InChi:

InChi=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(32-21) 1 9)20)11-3-2-10 (6-13 (11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

Furaha InChi:

MPGRAKIAJJGMM-OCCSQVGLSA-N

Ereyga muhiimka ah:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Xalka: 

Kaydinta: 

Sharaxaad:

Voruciclib, oo sidoo kale loo yaqaan P1446A-05, waa borotiinka kinase inhibitor gaar ah kinase 4 (CDK4) ku tiirsan cyclin oo leh firfircoonida antineoplastic. CDK4 inhibitor P1446A-05 waxay si gaar ah u joojisaa CDK4-dhexdhexaadinta G1-S marxaladda kala-guurka, xiritaanka baaskiilka unugyada iyo joojinta koritaanka unugyada kansarka. Serine / threonine kinase CDK4 waxaa laga helaa isku-dhafan oo leh nooca D-nooca G1 cyclins waana kinase-kii ugu horreeyay ee lagu dhaqo kicinta mitogenic, oo sii daaya unugyada marxaladda quiescent ee heerka wareegga wareegga G1 / S; Dhismayaasha CDK-cyclin ayaa la tusay inay fosphorylate fayriska retinoblastoma (Rb) horraantii G1, meesha ka saaraysa histone deacetylase (HDAC) iyo xannibaadda cadaadiska qoraalka.

Ujeedka: CDK4