BS-181

Magaca Kiimikada:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a] pyrimidine-5,7-diamine hydrochloride

Koodhka dhoola cadeynta:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Koodhka InChi:

InChi=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(27-22) 19)28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3, (H,24,27);1H

Furaha InChi:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Ereyga muhiimka ah:

Xalka: 

Kaydinta: 

Sharaxaad:

BS-181 waa CDK inhibitor aad u dooratey CDK7 oo leh IC(50) ee 21 nmol/L. Tijaabada CDK-yada kale iyo sidoo kale 69 kinase oo kale ayaa muujisay in BS-181 kaliya ay joojisay CDK2 xajmiyada ka hooseeya 1 micromol/L, iyadoo CDK2 laga mamnuucay 35-laab in ka yar (IC(50) 880 nmol/L) marka loo eego CDK7. Unugyada MCF-7, BS-181 waxay joojiyeen fosforyaalka CDK7 substrates, kor u qaadista wareegga unugyada iyo apoptosis si loo xakameeyo koritaanka khadadka unugyada kansarka, waxayna muujisay saameynta antitumor ee vivo.

Ujeedka: CDK7