Tropifexor

Chemical Name:

2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8- yl) -4-fluorobenzo[d]thiazole-6-carboxylic acid

SMILES Kodhi:

FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C(O)=O)C=C7S6)[C@H](CC5)C4

InChi Code:

InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18(11-16)39-13-20-24( 35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14, 16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+

InChi Key:

VYLOOGHLKSNNEK-PIIMJCKOSA-N

Keyword:

Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

Tropifexor (compound 1) inyowani uye ine simba kwazvo agonist yeFXR ine EC50 ye0.2 nM. Robust induction yezvose zviri zviviri BSEP uye SHP majini inoonekwa mumaseru ekutanga neTropifexor nenzira inotsamira. BSEP induction pamusoro pemotokari (DMSO) kutonga kunoonekwa pazvishoma zvakaderera se1 nM, nepo induction yakasimba yeSHP (15-fold pamusoro pemotokari) inocherechedzwa pa10 nM uye ine mwero induction yeSHP pa1 nM (3-fold) [1 ].

Chinangwa: FXR