Sitagliptin

Chemical Name:

Sitagliptin (INN; yakambozivikanwa seMK-0431 uye inotengeswa pasi pezita rekutengesa Januvia) ndeyemuromo antihyperglycemic (anti-diabetic drug) yedipeptidyl peptidase-4 (DPP-4) inhibitor class.

SMILES Kodhi:

O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O )(O)O.[H]O[H]

InChi Code:

InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13(7- 26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1, 2,3,4);1H2/t9-;;/m1../s1

InChi Key:

GQPYTJVDPQTBQC-KLQYNRQASA-N

Keyword:

Sitagliptin,Sitagliptin phosphate,Januvia,Glactiv,ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

Sitagliptin (INN; yakambozivikanwa seMK-0431 uye inotengeswa pasi pezita rekutengesa Januvia) ndeyemuromo antihyperglycemic (anti-diabetic drug) yedipeptidyl peptidase-4 (DPP-4) inhibitor class. Yakagadzirwa uye inotengeswa neMerck & Co. Iyi enzyme-inhibiting drug inoshandiswa iri yoga kana kusanganiswa nemamwe oral antihyperglycemic agents (akadai semetformin kana thiazolidinedione) pakurapa chirwere cheshuga mellitus type 2. Kubatsira kwemishonga iyi ndiko mhedzisiro yayo yakaderera (semuenzaniso, kushomeka kweshuga, kuderera kwehuremu) mukutonga kwehukoshi hweropa. Exenatide (Byetta) inoshandawo nemhedzisiro yayo pane incretin system.

Chinangwa: DPP-4