PRT-060318; PRT318; P142–76

Chemical Name:

2-((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide

SMILES Kodhi:

O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N

InChi Code:

InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1

InChi Key:

NZNTWOVDIXCHHS-LSDHHAIUSA-N

Keyword:

PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)

Tsanangudzo:

PRT060318 ine simba uye inosarudza inhibitor ye spleen tyrosine kinase (Syk; IC50 = 4 nM) .Inosarudza, inodzivisa 92% yeSyk basa, asi mamwe kinase anochengetedza> 70% basa, pamusangano we50 nM mupaneti ye. 270 kinases. PRT060318 inhibits convulxin-induced aggregation yeplasma-yakawanda yeplatelet yemunhu (IC50 = 2.5 μM) in vitro uye inodzivirira thrombosis mu transgenic mouse model ye heparin-induced thrombocytopenia. Inokonzera chronic lymphocytic leukemia (CLL) B cell apoptosis uye inhibits secretion ye chemokines CCL3, CCL4, uye CXCL13.3 PRT060318 inodzivisawo CLL B cell chemotaxis uye pseudoemperipolesis.

Chinangwa: Syk