NTN21277
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
Chemical Name:
(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino))-7-methoxyquinazolin-6-yl) oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
SMILES Kodhi:
O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC )=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
InChi Code:
InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57) 26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9- 14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55, 58)(H,51,52,54)/t33-,38+,43-/m1/s1
InChi Key:
NICKHWYZMNLEPJ-TZSMONEZSA-N
Keyword:
Gefitinib-based PROTAC 3; NTN21277; NTN-21277; NTN 21277
Solubility:
Kuchengeta:
Tsanangudzo:
NTN21277, inozivikanwawo seGefitinib-based PROTAC 3 inonzi VHL-recruiting PROTAC inokonzera kusvibiswa kweEGFR neEGFR mutants ine DC50 ye11.7 nM uye 22.3 nM yeHCC827 cell (Exon 19 del) uye H3255R cell (L8255R).
Chinangwa: EGFR
