Trelagliptin

Igoa vaila'au:

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile succinate

SMILES Code:

N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[C@H](N)CCC3)=CC2=O

InChi Code:

InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14( 19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1

InChi Key:

IWYJYHUNXVAVAA-OAHLLOKOSA-N

upu autu:

Trelagliptin, Trelagliptin succinate, SYR-472, Zafatek, 865759-25-7, 1029877-94-8

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

Trelagliptin, lea e taʻua foi o le SYR-472, o se inhibitor dipeptidyl peptidase-4 (DPP-4) umi e galue o loʻo atiaʻe e Takeda mo togafitiga o le maʻisuka ituaiga 2 (T2D). Fa'atasi ile vaiaso ole SYR-472 togafitiga na maua mai ile falema'i ma fa'afuainumera fa'alelei taua ile puleaina ole glycemic ile ma'i e maua ile ma'isuka ituaiga 2. Sa talia lelei ma e ono avea ma se togafiti fou mo gasegase ua maua i lenei ma'i. Trelagliptin (Zafatek(®)) na faʻamaonia i Iapani mo togafitiga o le maʻisuka ituaiga 2 (T2DM).

Sini: DPP-4