Linagliptin
Fa'amatalaga Oloa
Faailoga o oloa
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Igoa vaila'au:
8-[(3R) -3-aminopiperidin-1-yl]-7-(ae-2-yn-1-yl) -3- methyl-1-[(4-methylquinazolin-2-yl)methyl] -3 ,7-dihydro-1H-purine-2,6-dione
SMILES Code:
O=C(N1CC2=NC(C)=C3C=CC=CC3=N2)N(C)C4=C(N(CC#CC)C(N5C[C@H](N)CCC5)=N4)C1 =O
InChi Code:
InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35) 33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9, 12-15,26H2,1-3H3/t17-/m1/s1
InChi Key:
LTXREWYXXSTFRX-QGZVFWFLSA-N
upu autu:
Linagliptin, BI-1356, BI 1356, BI1356, 668270-12-0
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
Linagliptin, lea e lauiloa foi o le BI-1356, o se inhibitor DPP-4 na fausia e Boehringer Ingelheim mo togafitiga o le maʻisuka ituaiga II. Linagliptin (tasi i aso uma) na faʻamaonia e le US FDA i le aso 2 Me 2011 mo togafitiga o le maʻisuka ituaiga II. O loʻo faʻatauina e Boehringer Ingelheim ma Lilly.
Sini: DPP-4
