PRT-060318; PRT318; P142–76
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 500mg | E tele | 900 |
| 1g | E tele | 1350 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide
SMILES Code:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
InChi Code:
InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22, 23,24)/t14-,15+/m0/s1
InChi Key:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
upu autu:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)
Fa'amatalaga:
PRT060318 o se inhibitor malosi ma filifili ole spleen tyrosine kinase (Syk; IC50 = 4 nM) .E filifilia, faʻalavelaveina le 92% o le gaioiga Syk, ae o isi kinases o loʻo taofia le> 70% gaioiga, i le faʻatonuga o le 50 nM i se laulau o 270 kinase. O le PRT060318 e taofia ai le fa'atupuina o le convulxin i le fa'atupuina o le plasma toto (IC50 = 2.5 μM) in vitro ma puipuia ai le thrombosis i se fa'ata'ita'iga o le kiore transgenic o le thrombocytopenia fa'aosoina o le heparin. E faʻaosoina le leukemia lymphocytic tumau (CLL) B cell apoptosis ma faʻalavelaveina le faʻaogaina o chemokines CCL3, CCL4, ma le CXCL13.3 PRT060318 faʻalavelave foi CLL B cell chemotaxis ma pseudoemperipolesis.
Sini: Syk
