FAIGA 61-3606 2HCl

FAIGA 61-3606 2HCl
  • Igoa:FAIGA 61-3606 2HCl
  • Numera fa'amaumauga:CPDD1851
  • Numera CAS:648903-57-5
  • Molecular Weight:390.4
  • Fua Fa'atatau ole vaila'au:C20H18N6O3
  • Mo na'o su'esu'ega fa'asaienisi, ae le mo gasegase.

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    Igoa vaila'au:

    2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride

    SMILES Code:

    O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl

    InChi Code:

    InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20 (24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24 ,25);2*1H

    InChi Key:

    SPMFEULFGGPQLN-UHFFFAOYSA-N

    upu autu:

    BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

    Solubility:Solu i le DMSO

    Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

    Fa'amatalaga:

    BAY 61-3606 o se malosi malosi (Ki = 7.5 nM) ma le faʻamalosi filifilia o Syk kinase. BAY 61-3606 taofia e le gata degranulation (IC50 tau i le va o 5 ma 46 nM) ae faapea foi lipid mediator ma cytokine synthesis i sela mast. BAY 61-3606 sa sili ona aoga i basophils maua mai tagata soifua maloloina (IC50 = 10 nM) ma foliga mai e sili atu le malosi i basophils maua mai atopic (high serum IgE) mataupu (IC50 = 8.1 nM). O le faʻagaioiina o le faʻaogaina o le cell B ma le tali atu mo le vaega Fc o le IgG faʻailoga i eosinophils ma monocytes na mafai foi ona taofiofia malosi e le BAY 61-3606.

    Sini: Syk


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