JBJ-04-125-02 R-isomer
Fa'amatalaga Oloa
Faailoga o oloa
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Igoa vaila'au:
(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl)acetamide
SMILES Code:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
InChi Code:
InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28( 35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8,11,14-16,26,31,36H,9- 10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
InChi Key:
VHQVOTINPRYDAO-AREMUKBSSA-N
upu autu:
Solubility:
Teuina:
Fa'amatalaga:
JBJ-04-125-02 ose mutant-filifiliga EGFR allosteric inhibitor ma ono mafai anticancer gaoioiga. I le avea ai o se sui e tasi, e mafai ona faʻalavelaveina le faʻateleina o le cell ma le EGFRL858R / T790M / C797S faʻailoga i vitro ma in vivo. O le tuʻufaʻatasiga o le osimertinib ma le JBJ-04-125-02 e mafua ai le faʻateleina o le apoptosis, o se faʻalavelave sili atu ona lelei o le tuputupu aʻe o le telefoni feaveaʻi, ma le faʻateleina o le aoga i vitro ma in vivo pe a faʻatusatusa i se sui e tasi.
Sini: EGFR
