GDC-0326

GDC-0326
  • Igoa:GDC-0326
  • Numera fa'amaumauga:CPDD3857
  • Numera CAS:1282514-88-8
  • Molecular Weight:382.424
  • Fua Fa'atatau ole vaila'au:C19H22N6O3
  • Mo na'o su'esu'ega fa'asaienisi, ae le mo gasegase.

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    Igoa vaila'au:

    (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4] ]oxazepin-9-yl)oxy)propanamide

    SMILES Code:

    C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

    InChi Code:

    InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3) )17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/ m0/s1

    InChi Key:

    SIKYDKLGPWRPMZ-LBPRGKRZSA-N

    upu autu:

    GDC-0326, GDC0326, GDC 0326, 1282514-88-8

    Solubility:Solu i le DMSO

    Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

    Fa'amatalaga:

    GDC-0326 o se inhibitor malosi ma filifili ole α-Isoform o Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 ausia se maualuga maualuga maualuga o le filifilia i luga o isi kinases. GDC-0326 e maualalo le plasma CL ile tagata. I totonu o le aiga PI3 kinase, e fa vasega I PI3K isoforms (α, β, δ, ma le γ). Mai nei isoforms, PI3Kα e sili ona masani ona fesoʻotaʻi ma kanesa.

    Sini: PI3K


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