AMG-510
Fa'amatalaga Oloa
Faailoga o oloa
Tele o le afifi | Avanoa | Tau (USD) |
1g | e tele | 1300 |
5g | e tele | 6000 |
10g | e tele | 10500 |
Igoa vaila'au:
4-((S)-4-acrylyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl )pyrido[2,3-d]pyrimidin-2(1H)-tasi
SMILES Code:
O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4)=O)CC1
InChi Code:
InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6- 11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChi Key:
NXQKSXLFSAEQCZ-SFHVURJKSA-N
upu autu:
AMG-510; AMG 510; AMG510
Solubility:
Teuina:
Fa'amatalaga:
AMG-510 o se KRAS G12C covalent inhibitor malosi. AMG-510 filifili fa'atatau ile KRAS p.G12C mutant, i le DNA, RNA po'o le porotini, ma puipuia, e ala i se auala e le'i fa'amalamalamaina, fa'aaliga o ma/po'o le tumo fa'ailo e ala ile KRAS p.G12C mutant. E ono taofia ai le tupu a'e o le KRAS p.G12C-fa'aalia sela tumo
Sini: KRAS