AZD8186

AZD8186
  • Igoa:AZD8186
  • Numera fa'amaumauga:CPDB0202
  • Numera CAS:1627494-13-6
  • Molecular Weight:457.4
  • Fua Fa'atatau ole vaila'au:C24H25F2N3O4
  • Mo na'o su'esu'ega fa'asaienisi, ae le mo gasegase.

    Fa'amatalaga Oloa

    Faailoga o oloa

    Tele o le afifi Avanoa Tau (USD)
    100mg E tele 350
    500mg E tele 700
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    Igoa vaila'au:

    (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

    SMILES Code:

    O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

    InChi Code:

    InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 )9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1

    InChi Key:

    LMJFJIDLEAWOQJ-CQSZACIVSA-N

    upu autu:

    AZD8186, AZD-8186, AZD 8186, 1627494-13-6

    Solubility:Solu i le DMSO

    Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

    Fa'amatalaga:

    AZD8186 o loʻo ma le inhibitor ole beta isoform o le phosphoinositide-3 kinase (PI3K), faʻatasi ai ma gaioiga antineoplastic. I luga o le pulega, PI3Kbeta inhibitor AZD8186 filifili faʻalavelave le gaioiga o le PI3Kbeta i le ala faʻailoga PI3K / Akt / mTOR, lea e ono iʻu ai i le faʻaitiitia o le faʻalauteleina o le tumo. E fa'aosoina ai fo'i le oti i le PI3K-fa'aalia sela o le kanesa. E ala i le tulituliloaina faapitoa o le vasega I PI3K beta, atonu e sili atu le aoga o lenei sooupu ma itiiti le oona nai lo pan PI3K iniseti. PI3K-mediated faʻailoga e masani ona faʻasalaina i sela o le kanesa ma fesoasoani i le faʻateleina o le tuputupu aʻe o le tumo, ola, ma le teteʻe o le tumo i le tele o vailaʻau antineoplastic. AZD8186 o loʻo i lalo o le Vaega I faʻataʻitaʻiga falemaʻi.

    Sini: PI3K


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