Quizartinib; AC-010220; AC-220

Igoa vaila'au:

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl}urea

SMILES Code:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6

InChi Code:

InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

InChi Key:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

upu autu:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

O Quizartinib o se faʻalavelave ole FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) ma faʻaalia le maualuga o le filifilia mo FLT3 pe a faʻataʻitaʻiina i se laulau o 227 kinases faaopoopo. E taofia ai le faʻateleina o le tagata leukemia cell line MV4-11, lea o loʻo i ai se suiga FLT3-ITD homozygous, faʻatasi ai ma le tau IC50 o le 0.56 nM.1 I le 1 mg / kg / aso, quizartinib ua faʻaalia e faʻalautele le ola i se isumu. faʻataʻitaʻiga o le FLT3-ITD acute myeloid leukemia ma faʻaumatia tuma i se faʻataʻitaʻiga xenograft kiore FLT3 faʻalagolago ile 10 mg/kg.

Sini: FLT3