BAZ2-ICR

Izina ryimiti:

4- (4- (1-methyl-1H-pyrazol-4-yl) -1- (2- (1-methyl-1H-pyrazol-4-yl) ethyl) -1H-imidazol-5-yl) benzonitrile

Kode ya SMILES:

CN (N = C1) C = C1C2 = C (C3 = CC = C (C # N) C = C3) N (CCC4 = CN (C) N = C4) C = N2

InChi Code:

InChI = 1S / C20H19N7 / c1-25-12-16 (10-23-25) 7-8-27-14-22-19 (18-11-24-26 (2) 13-18) 20 (27) 17-5-3-15 (9-21) 4-6-17 / h3-6,10-14H, 7-8H2,1-2H3

InChi Urufunguzo:

RRZVGDGTWNQAPW-UHFFFAOYSA-N

Ijambo ryibanze:

BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

BAZ2-ICR nubushakashatsi bwiza bwimiti yubushakashatsi bukora kuri BAZ2 bromodomain muri vitro no muri vivo. Bromodomain irimo proteyine BAZ2A / B igira uruhare runini muguhindura chromatin no kugenzura RNAs idafite kodegisi. BAZ2-ICR ifite IC50 (BAZ2A) = 130 nM; IC50 (BAZ2B) = 180 nM; logD = 1.05; gukemura 25 mM (D2O) na F = 70%.

Intego: BAZ2