GLPG0187

Izina ryimiti:

(S) -3 - ((2,5-dimethyl-6- (4 - yl) amino) -2 - (((4-mikorerexyphenyl) sulfonamido) aside protanoic

Kode ya SMILES:

O = C (O) [C @ H] (CNC1 = NC (C) = NC (N2CCC C (OC) C = C5) = O.

InChi Code:

InChI = 1S / C29H37N7O5S / c1-18-26 (31-17-25 (29 (37) 38) 35-42 (39,40) 23-9-7-22 (41-3) 8-10-23) 32-19 (2) 33-28 (18) 36-15-12-20 (13-16-36) 24-11-6-21-5-4-14-30-27 (21) 34-24 / h6-11,20,25,35H, 4-5,12-17H2,1-3H3, (H, 30,34) (H, 37,38) (H, 31,32,33) / t25- / m0 / s1

InChi Urufunguzo:

CXHCNOMGODVIKB-VWLOTQADSA-N

Ijambo ryibanze:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Mu cyiciro gikomeye, GLPG0187 yerekana guhitamo kubantu benshi ba RGD integrin yakira hamwe na IC50s ya 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM kuri αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, na α5β1. GLPG0187 ni inzitizi ikomeye yo guhagarika amagufwa ya osteoclastique na angiogenez. Umuti hamwe na GLPG0187 ikinini-biterwa byongera igipimo cya E-cadherin / vimentin, bigatuma selile zirushaho kuba epiteliyale, sessile phenotype. GLPG0187 ikoreshwa cyane igabanya ubunini bwa aldehyde dehydrogenase subpopulation ya kanseri ya prostate [1]. GLPG0187 ivura ibisubizo muburyo bwo kuzunguruka no gufunga. GLPG0187 yerekana igabanuka rishingiye ku kugabanuka gukabije kwimuka kwimuka. GLPG0187 yibitekerezo byose bigabanya cyane ikwirakwizwa rya selile [2].

Intego: αvβ1