Vactosertib

Izina ryimiti:

N - ((4 - ([1,2,4] triazolo [1,5-a] pyridin-6-yl) -5- (6-methylpyridin-2-yl) -1H-imidazol-2-yl) methyl ) -2-fluoroaniline

Kode ya SMILES:

FC1 = CC = CC = C1NCC2 = NC (C3 = CN4C (C = C3) = NC = N4) = C (C5 = NC (C) = CC = C5) N2

InChi Code:

InChI = 1S / C22H18FN7 / c1-14-5-4-8-18 (27-14) 22-21 (15-9-10-20-25-13-26-30 (20) 12-15) 28- 19 (29-22) 11-24-17-7-3-2-6-16 (17) 23 / h2-10,12-13,24H, 11H2,1H3, (H, 28,29)

InChi Urufunguzo:

FJCDSQATIJKQKA-UHFFFAOYSA-N

Ijambo ryibanze:

Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

Vactosertib, izwi kandi nka EW-7197 ni inhibitor ikomeye ALK5. EW-7197 yerekanye imbaraga mubikorwa bya vivo birwanya metastatike, byerekana ubushobozi bwayo bwo gukoresha nkumuti urwanya kanseri. EW-7197 ibuza ibimenyetso bya TGF-β / Smad. EW-7197 ikuraho TGF-β1-iterwa no kubyimba ingirabuzimafatizo no gutera. EW-7197 ibuza kanseri y'ibere metastasis mu bihaha.EW-7197 yongerera igihe cyo kubaho kwimbeba za BALB / c 4T1 hakoreshejwe kubuza EMT. EW-7197 ibuza metastasis kandi ikongera ibikorwa bya lymphocytes ya cytotoxic T (CTLs) muri 4T1 imbeba ya orthotopique.

Intego: ALK