ND-630

ND-630
  • Izina:ND-630
  • Cataloge No.:CPD1592
  • CAS No.:1434635-54-7
  • Uburemere bwa molekile:569.63
  • Imiti yimiti:C28H31N3O8S
  • Kubushakashatsi bwa siyansi gusa, ntabwo kubarwayi.

    Ibicuruzwa birambuye

    Ibicuruzwa

    Ingano Kuboneka Igiciro (USD)
    10mg Mububiko 300
    50mg Mububiko 500
    100mg Mububiko 800
    Ingano nini Shaka Amagambo Shaka Amagambo

    Izina ryimiti:

    (R) -2- (1- (2- (2-mikorerexyphenyl) -2 - -2,4-dioxo-1,2-dihydrothieno [2,3-d] pyrimidin-3 (4H) -yl) -2-methylpropanamide

    Kode ya SMILES:

    O = C (N) C (C) (C) N (C (N (C [C @@ H] (C1 = CC = CC = C1OC) OC2CCOCC2) C3 = C4C (C) = C (C5 = NC = CO5) S3) = O) C4 = O.

    InChi Code:

    InChI = 1S / C28H31N3O8S / c1-16-21-24 (32) 31 (28 (2,3) 26 (33) 34) 27 (35) 30 (25 (21) 40-22 (16) 23-29- 11-14-38-23) 15-20 (3 9-17-9-12-37-13-10-17) 18-7-5-6-8-19 (18) 36-4 / h5-8,11,14,17,20H, 9-10, 12-13,15H2,1-4H3, (H, 33,34) / t20- / m0 / s1

    InChi Urufunguzo:

    ZZWWXIBKLBMSCS-FQEVSTJZSA-N

    Ijambo ryibanze:

    ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7

    Gukemura:Gukemura muri DMSO

    Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

    Ibisobanuro:

    ND-630 ibuza HACC1 (IC50 = 2.1 ± 0.2 nM) na HACC2 (IC50 = 6.1 ± 0.8 nM). Kubuzwa birahindurwa kandi byihariye kuri ACC. ND-630 ibuza ibikorwa bya ACC ikorana na fosifopteptide-yakira hamwe na dimerisation ya enzyme kugirango ikumire. ND-630 ibuza synthesis ya aside irike hamwe na EC50 ya 66 nM muri selile ya HepG2 idahinduye umubare wuzuye wa selile, intungamubiri za poroteyine, hamwe no kwinjiza acetate muri cholesterol [1].

    Intego: ACC




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