TH-302; Evofosfamide

TH-302; Evofosfamide
  • Izina:TH-302; Evofosfamide
  • Cataloge No.:CPDB1510
  • CAS No.:918633-87-1
  • Uburemere bwa molekile:449.04
  • Imiti yimiti:C9H16Br2N5O4P
  • Kubushakashatsi bwa siyansi gusa, ntabwo kubarwayi.

    Ibicuruzwa birambuye

    Ibicuruzwa

    Ingano Kuboneka Igiciro (USD)
    100mg Mububiko 360
    1g Mububiko 1000
    Ingano nini Shaka Amagambo Shaka Amagambo

    Izina ryimiti:

    N, N'-Bis (2-bromoethyl) fosifore ya fosifori (1-methyl-2-nitro-1H-imidazol-5-yl) methyl ester

    Kode ya SMILES:

    O = P (NCCBr) (NCCBr) OCC1 = CN = C ([N +] ([O -]) = O) N1C

    InChi Code:

    InChI = 1S / C9H16Br2N5O4P / c1-15-8 (6-12-9 (15) 16 (17) 18) 7-20-21 (19,13-4-2-10) 14-5-3-11 / h6H, 2-5,7H2,1H3, (H2,13,14,19)

    InChi Urufunguzo:

    UGJWRPJDTDGERK-UHFFFAOYSA-N

    Ijambo ryibanze:

    TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

    Gukemura:Gukemura muri DMSO

    Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

    Ibisobanuro:

    Evofosfamide, izwi kandi nka TH-302, ni prodrug ikora hypoxia igizwe na 2-nitroimidazole phosphoramidate conjugate hamwe nibikorwa bya antineoplastique. Imyuka ya 2-nitroimidazole ya hypoxia ikora prodrug TH-302 ikora nka hypoxic trigger, irekura ADN-alkylating dibromo isophosphoramide ya sinapi mu turere twa hypoxique yibibyimba. Uturemangingo twa Normoxic dushobora kurindwa kubera ibikorwa byihariye bya hypoxia yiyi agent, birashobora kugabanya uburozi bwa sisitemu. Reba ibizamini bya clinique ikora cyangwa ibizamini bya clinique bifunze ukoresheje iyi agent. (NCI).

    Intego: Umukozi wa ADN ya Alkylating


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