TH-302; Evofosfamide
Ibicuruzwa birambuye
Ibicuruzwa
Ingano | Kuboneka | Igiciro (USD) |
100mg | Mububiko | 360 |
1g | Mububiko | 1000 |
Ingano nini | Shaka Amagambo | Shaka Amagambo |
Izina ryimiti:
N, N'-Bis (2-bromoethyl) fosifore ya fosifori (1-methyl-2-nitro-1H-imidazol-5-yl) methyl ester
Kode ya SMILES:
O = P (NCCBr) (NCCBr) OCC1 = CN = C ([N +] ([O -]) = O) N1C
InChi Code:
InChI = 1S / C9H16Br2N5O4P / c1-15-8 (6-12-9 (15) 16 (17) 18) 7-20-21 (19,13-4-2-10) 14-5-3-11 / h6H, 2-5,7H2,1H3, (H2,13,14,19)
InChi Urufunguzo:
UGJWRPJDTDGERK-UHFFFAOYSA-N
Ijambo ryibanze:
TH-302, TH302, TH 302, Evofosfamide, 918633-87-1
Gukemura:Gukemura muri DMSO
Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)
Ibisobanuro:
Evofosfamide, izwi kandi nka TH-302, ni prodrug ikora hypoxia igizwe na 2-nitroimidazole phosphoramidate conjugate hamwe nibikorwa bya antineoplastique. Imyuka ya 2-nitroimidazole ya hypoxia ikora prodrug TH-302 ikora nka hypoxic trigger, irekura ADN-alkylating dibromo isophosphoramide ya sinapi mu turere twa hypoxique yibibyimba. Uturemangingo twa Normoxic dushobora kurindwa kubera ibikorwa byihariye bya hypoxia yiyi agent, birashobora kugabanya uburozi bwa sisitemu. Reba ibizamini bya clinique ikora cyangwa ibizamini bya clinique bifunze ukoresheje iyi agent. (NCI).
Intego: Umukozi wa ADN ya Alkylating