BLU-9931

Izina ryimiti:

N- (2 - ((6- (2,6-dichloro-3,5-dimethoxyphenyl) quinazolin-2-yl) amino) -3-methylphenyl) acrylamide

Kode ya SMILES:

C = CC (NC1 = CC = CC (C) = C1NC2 = NC = C3C = C (C4 = C (Cl) C (OC) = CC (OC) = C4Cl) C = CC3 = N2) = O

InChi Code:

InChI = 1S / C26H22Cl2N4O3 / c1-5-21 (33) 30-18-8-6-7-14 (2) 25 (18) 32-26-29-13-16-11-15 (9-10- 17 (16) 31-26) 22-23 (27) 19 (34-3) 12-20 (35-4) 24 (22) 28 / h5-13H, 1H2,2-4H3, (H, 30,33 ) (H, 29,31,32)

InChi Urufunguzo:

TXEBNKKOLVBTFK-UHFFFAOYSA-N

Ijambo ryibanze:

BLU-9931, BLU9931, BLU 9931, 1538604-68-0

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Muri selile MDA-MB-453, BLU9931 irabuza cyane fosifora ya FGFR4 yerekana inzira. BLU9931 irabuza ikwirakwizwa ryimirongo ya selire ya HCC yerekana ibimenyetso byerekana ibimenyetso bya FGFR4, nka Hep 3B, HUH-7, na JHH-7, hamwe na EC50 ya<1 μM. BLU9931 irabuza kandi gukwirakwira mumirongo ngengabuzima ikomoka kuri PDX hamwe n'inzira yerekana FGFR4 yerekana inzira [1]. BLU9931 itera kugabanuka kw'ibibyimba mu bwoko bwa kanseri ya hepatocellular yerekana kanseri ikora ligand / reseptor ikora igizwe na FGF19 / FGFR4 / KLB kandi ikiyongera ku rutonde rwiyongera rw'imiti irwanya FGFR4 [2].

Intego: FGFR4