ARS-1620

Izina ryimiti:

(S) -1- (4-.

Kode ya SMILES:

C = CC (= O) N1CCN (CC1) C2 = C3C = C (C (= C4C (= O) C = CC = C4F) C (= C3NC = N2) F) Cl

InChi Code:

InChI = 1S / C21H17ClF2N4O2 / c1-2-16 (30) 27-6-8-28 (9-7-27) 21-12-10-13 (22) 17 (19 (24) 20 (12) 25- 11-26-21) 18-14 (23) 4-3-5-15 (18) 29 / h2-5,10-11,29H, 1,6-9H2

InChi Urufunguzo:

QIQWMIZVWVSRAS-UHFFFAOYSA-N

Ijambo ryibanze:

ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

ARS-1620 ni prodrug yakozwe kuva ARS-853, ikaba ikomeye kandi ihitamo S-IIP G12C inhibitor. Biteganijwe ko ARS-1620 izaba ingamba zo kuvura kanseri ya p.G12C KRAS.

Intego: KRAS (K-Ras G12C)