BLU-667

Izina ryimiti:

. (1s, 4R) -N - ((S) -1- (4- (5-methyl-1H-pyrazol-3-yl) amino) pyrimidin-2-yl) cyclohexane-1-carboxamide

Kode ya SMILES:

CC1 = NC ([C @@ H] 2CC [C @] (C (N [C @@ H] (C) C3 = CC = C (N4N = CC (F) = C4) C = C3) = O) (OC) CC2) = NC (NC5 = NNC (C) = C5) = C1

InChi Code:

InChI = 1S / C28H33FN8O2 / c1-17-13-24 (33-25-14-18 (2) 35-36-25) 34-26 (31-17) 21-9-11-28 (39-4, 12-10-21) 27 (38) 32-19 (3) 20-5-7-23 (8-6-20) 37-16-22 (29) 15-30-37 / h5-8,13- 16,19,21H, 9-12H2,1-4H3, (H, 32,38) (H2,31,33,34,35,36) / t19-, 21-, 28 + / m0 / s1

InChi Urufunguzo:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Ijambo ryibanze:

BLU-667; BLU 667; BLU667

Gukemura:DMSO

Ububiko: 

Ibisobanuro:

BLU-667 ninzitizi ikomeye kandi ihitamo ibuza ihinduka ryimiterere ya RET, fusion, hamwe na mutant ihinduka. RET fusion ni moteri nyamukuru ya kanseri nyinshi, harimo kanseri y'ibihaha na tiroyide, kandi ubushakashatsi bwacu bwerekana ko RET nayo igira uruhare runini muri kanseri zimwe na zimwe. Mugihe kimwe yibasiye umushoferi wibanze kandi byahanuye ihinduka ryimiterere itera kanseri ya kanseri itita kubuvuzi hamwe nibiyobyabwenge byemewe,

Intego: GUSUBIZA