PRT-060318; PRT318; P142-76
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 500 mg | Zilipo | 900 |
| 1g | Zilipo | 1350 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide
SMILES Kodi:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
InChi kodi:
InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1
InChi Key:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
Mawu ofunika:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
PRT060318 ndi inhibitor yamphamvu komanso yosankha ya spleen tyrosine kinase (Syk; IC50 = 4 nM). Imasankha, imalepheretsa 92% ya zochita za Syk, pamene kinase ena amasunga> 70% ntchito, pamagulu a 50 nM mu gulu la 270 magalamu. PRT060318 imalepheretsa kuphatikizika kwa plasma yamunthu yokhala ndi mapulateleti (IC50 = 2.5 μM) mu vitro ndikuletsa thrombosis mu mtundu wa mbewa wa transgenic wa heparin-induced thrombocytopenia. Amayambitsa matenda a lymphocytic leukemia (CLL) B cell apoptosis ndipo amalepheretsa kutuluka kwa chemokines CCL3, CCL4, ndi CXCL13.3 PRT060318 imalepheretsanso CLL B cell chemotaxis ndi pseudoemperipolesis.
Cholinga: Syk
