Chithunzi cha BAY 61-3606 2HCl
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 1g | Zilipo | 1200 |
| 10g pa | Zilipo | 5000 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride
SMILES Kodi:
O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl
InChi kodi:
InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24- 14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) 2*1 uwu
InChi Key:
SPMFELFGGPQLN-UHFFFAOYSA-N
Mawu ofunika:
BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
BAY 61-3606 ndi yamphamvu (Ki = 7.5 nM) ndi inhibitor yosankha ya Syk kinase. BAY 61-3606 inaletsa osati degranulation (makhalidwe a IC50 pakati pa 5 ndi 46 nM) komanso lipid mediator ndi cytokine synthesis m'maselo a mast. BAY 61-3606 inali yothandiza kwambiri mu basophils yopezedwa kuchokera kwa anthu athanzi (IC50 = 10 nM) ndipo ikuwoneka ngati yamphamvu kwambiri mu basophils yopezedwa kuchokera ku atopic (high serum IgE) maphunziro (IC50 = 8.1 nM). B cell receptor activation ndi ma receptor a Fc gawo la IgG signing mu eosinophils ndi monocytes adaponderezedwanso mwamphamvu ndi BAY 61-3606.
Cholinga: Syk
