NTN21277
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Isem Kimiku:
(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino))-7-methoxyquinazolin-6-yl) ossi)pentil)ossi)eth ossi)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Kodiċi SMILES:
O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F))C(Cl)=C4)N=CN=C3C=C2OC )=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Kodiċi InChi:
InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-3 3(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8- 17-64-40-23-34-37 (24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24 ,27-28,33,3 8,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33- ,38+,43-/m1/s1
InChi Key:
NICKHWYZMNLEPJ-TZSMONEZSA-N
Keyword:
PROTAC 3 ibbażat fuq Gefitinib; NTN21277; NTN-21277; NTN 21277
Solubilità:
Ħażna:
Deskrizzjoni:
NTN21277, magħruf ukoll bħala PROTAC 3 ibbażat fuq Gefitinib huwa PROTAC li jirrekluta VHL li jinduċi d-degradazzjoni ta 'mutanti EGFR u EGFR b'DC50 ta' 11.7 nM u 22.3 nM għal ċellula HCC827 (Exon 19 del) u ċellula H3255 (L858R).
Mira: EGFR
