AMG-510
Dettall tal-Prodott
Tags tal-Prodott
| Daqs tal-Pakkett | Disponibbiltà | Prezz (USD) |
| 1g | fl-istokk | 1300 |
| 5g | fl-istokk | 6000 |
| 10g | fl-istokk | 10500 |
Isem Kimiku:
4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl )pirido[2,3-d]pirimidin-2(1H)-one
Kodiċi SMILES:
O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C) (C5=C(O)C=CC=C5F)=N4)=O)CC1
Kodiċi InChi:
InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22(24)39)34 -29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1 ,12-13,15H2,2-5H3/t18-/m0/s1
InChi Key:
NXQKSXLFSAEQCZ-SFHVURJKSA-N
Keyword:
AMG-510; AMG 510; AMG510
Solubilità:
Ħażna:
Deskrizzjoni:
AMG-510 huwa inibitur kovalenti KRAS G12C qawwi. AMG-510 jimmira b'mod selettiv lill-mutant KRAS p.G12C, jew fil-livell tad-DNA, RNA jew proteina, u jipprevjeni, permezz ta' mod li għadu mhux spjegat, l-espressjoni ta' u/jew is-sinjalar taċ-ċelluli tat-tumur permezz tal-mutant KRAS p.G12C. Dan jista 'jinibixxi t-tkabbir fiċ-ċelloli tat-tumur li jesprimu KRAS p.G12C
Mira: KRAS
