Trelagliptin

Ingoa matū:

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile succinate

Waehere SMILES:

N#CC1=CC=C(F)C=C1CN(C(N2C)=O)C(N3C[C@H](N)CCC3)=CC2=O

Waehere InChi:

InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)1 0-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1 /s1

Kī InChi:

IWYJYHUNXVAVAA-OAHLLOKOSA-N

Kupumatua:

Trelagliptin, Trelagliptin succinate, SYR-472, Zafatek, 865759-25-7, 1029877-94-8

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te Trelagliptin, e mohiotia ana ko SYR-472, he aukati roa o te dipeptidyl peptidase-4 (DPP-4) e hangaia ana e Takeda mo te maimoatanga o te mate huka momo 2 (T2D). Ko te maimoatanga SYR-472 kotahi-wiki i puta ai nga whakapainga haumanu me te tatauranga nui mo te whakahaere glycemic i nga turoro me te mate huka momo 2. I pai te whakamanawanui, a he momo rongoa hou pea mo nga turoro e pa ana ki tenei mate. Ko te Trelagliptin (Zafatek(®)) i whakaaetia i Hapani mo te maimoatanga o te mate huka momo 2 (T2DM).

Whāinga: DPP-4