Sitagliptin

Ingoa matū:

Ko te Sitagliptin (INN; i tohuhia i mua ko MK-0431 ka hokona i raro i te ingoa hokohoko Januvia) he antihyperglycemic-waha (taaru mate huka) o te akomanga aukati dipeptidyl peptidase-4 (DPP-4).

Waehere SMILES:

O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O )(O)O.[H]O[H]

Waehere InChi:

InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;( H3,1,2,3,4);1H2/t9-;;/m1../s1

Kī InChi:

GQPYTJVDPQTBQC-KLQYNRQASA-N

Kupumatua:

Sitagliptin,Sitagliptin phosphate,Januvia,Glactiv,ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te Sitagliptin (INN; i tohuhia i mua ko MK-0431 ka hokona i raro i te ingoa hokohoko Januvia) he antihyperglycemic-waha (taaru mate huka) o te akomanga aukati dipeptidyl peptidase-4 (DPP-4). I whakawhanakehia, i hokohokohia e Merck & Co. Ko tenei rongoa aukati i te whanariki ka whakamahia ko ia anake, ka hono tahi ranei me etahi atu raau taero antihyperglycemic-waha (penei i te metformin, te thiazolidinedione ranei) mo te maimoatanga o te mate huka momo 2. Ko te painga o tenei rongoa ko te ko ona paanga taha iti (hei tauira, he iti te hypoglycemia, he iti ake te taumaha) ki te whakahaere i nga uara huka toto. Ka mahi ano a Exenatide (Byetta) ma tana paanga ki te punaha incretin.

Whāinga: DPP-4