TAS-120

Ingoa matū:

1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-one

Waehere SMILES:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

Waehere InChi:

InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2 ,23,24,25)/t15-/m0/s1

Kī InChi:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Kupumatua:

TAS-120

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko te TAS-120 he aukati koiora-a-waha o te kaikawe fibroblast growth factor (FGFR) me te mahi antineoplastic pea. Ko te kaiwawao FGFR TAS-120 ka herea me te kore e taea te here me te aukati i te FGFR, ka puta pea te aukati i te ara whakawhiti tohu tohu-whakawaenga a FGFR me te tipu o te pūtau puku, me te nui ake o te mate o te pūtau i roto i nga pūtau pukupuku FGFR-overexpressing. Ko te FGFR he kaikawe tyrosine kinase e tika ana mo te tipu o te pūtau puku, te rereketanga me te oranga, me te whakataurite i ona korero i roto i te maha o nga momo pūtau puku.

Whāinga: FGFR