JBJ-04-125-02 R-isomer
Taipitopito Hua
Tohu Hua
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Ingoa matū:
(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl)acetamide
Waehere SMILES:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Waehere InChi:
InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28( 35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8,11,14-16,26,31,36H,9- 10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
Kī InChi:
VHQVOTINPRYDAO-AREMUKBSSA-N
Kupumatua:
Wairewa:
Rokiroki:
Whakaahuatanga:
Ko te JBJ-04-125-02 he kaitakawaenga EGFR allosteric kua tohua me te mahi anticancer pea. Hei kaihoko kotahi, ka taea e ia te aukati i te tipu o te pūtau me te tohu EGFRL858R / T790M / C797S i roto i te vitro me te vivo. Ko te whakakotahitanga o te osimertinib me te JBJ-04-125-02 ka hua te piki o te apoptosis, ka kaha ake te aukati i te tipu o te pūtau, me te kaha ake i roto i te vitro me te in vivo ka whakatauritehia ki te kaihoko kotahi anake.
Whāinga: EGFR
