EAI-045

Ingoa matū:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

Waehere SMILES:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Waehere InChi:

InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11- 3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

Kī InChi:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Kupumatua:

EAI-045, EAI045, EAI 045, 1942114-09-1

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko te EAI045 he kaikawe EGFR kaha me te whiriwhiri. Ko te EAI045 e whai ana i nga mutants EGFR-aukati tarukino kua tohua engari e tohungia ana te kaikawe momo mohoao. Ko te EAI045 te whakakore i te L858R / T790M-mutant EGFR me te kaha iti-nanomolar i roto i nga whakamatautau koiora.

Whāinga: EGFR