PCO371

Ingoa matū:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl )sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

Waehere SMILES:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F)F )C=C4)N5)C5=O)=O)C(C)=C2)=O

Waehere InChi:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30, 31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

Kī InChi:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

Kupumatua:

PCO371; PCO-371; PCO 371

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko te PCO371 he agonist PTHR1 kaha me te whiriwhiri mo te maimoatanga o te hypoparathyroidism. Ko te whakahaere a-waha o PCO371 ki nga kiore osteopenic ka whakapataritari i te pikinga nui o te huringa o nga wheua me te iti o te pikinga o te papatipu wheua. I roto i nga kiore hypocalcemic, ka whakahokia e te PCO371 nga taumata konupūmā serum me te kore e piki ake te konupūmā mimi, me te kaha ake me te roa o nga paanga atu i nga werohanga PTH.

Whāinga: PTHR1