Ozanimod

Ingoa matū:

(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2 -isopropoxybenzonitrile

Waehere SMILES:

N#CC1=CC(C2=NC(C3=CC=CC4=C3CC[C@@H]4NCCO)=NO2)=CC=C1OC(C)C

Waehere InChi:

InChI=1S/C23H24N4O3/c1-14(2)29-21-9-6-15(12-16(21)13-24)23-26-22(27-30-23)19-5-3- 4 -18-17(19)7-8-20(18)25-10-11-28/h3-6,9,12,14,20,25,28H,7-8,10-11H2,1-2H3 /t20-/m0/s1

Kī InChi:

XRVDGNKRPOAQTN-FQEVSTJZSA-N

Kupumatua:

Ozanimod, RPC-1063, RPC1063, RPC 1063, 1306760-87-1

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te Ozanimod he kaiwhakamaori whiriwhiri, e waatea ana ma te waha o nga kaiwhakawhiwhi sphingosine-1-phosphate (S1P) S1P1 me SIP5. Ka whakaawe i te whakaurunga o te S1P1, ka whakaheke i te rere o te B me te CCR7(+) T lymphocytes, me te whakaheke i te mumura me nga tawhā mate i roto i nga tauira mate autoimmune e toru.1 Kei roto a Ozanimod i nga whakamatautau haumanu mo te whakahoki mai i te sclerosis maha me te ulcerative colitis.

Whāinga: S1P