OTS964

Ingoa matū:

(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

Waehere SMILES:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4

Waehere InChi:

InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

Kī InChi:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Kupumatua:

OTS 964, OTS-964, OTS964, 1338545-07-5

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko OTS964 he aukati o te lymphokine-whakahohe kaikohuru T pūtau-taketake kinase pūmua (TOPK; IC50 = 28 nM). Ka aukati i te cytokinesis, ka puta ki te apoptosis, i roto i te whānuitanga o nga pūtau mate pukupuku. Ko te OTS964 e whakaohooho ana i te apoptosis o nga pūtau pukupuku mate pukupuku tangata i roto i nga xenografts kiore.

Whāinga: TOPK