IACS-010759

Ingoa matū:

5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl) -1,2,4-oxadiazole

Waehere SMILES:

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O))(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

Waehere InChi:

InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3

Kī InChi:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Kupumatua:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te IACS-010759, ko te IACS-10759 ranei he kaha me te whiriwhiri i te Oxidative Phosphorylation Inhibitor (IC50).<10 nM) me te mahi antineoplastic pea. Ka herea e te IACS-010759 me te aukati i te matatini I o te mekameka kawe irahiko (NADH ubiquinone oxidoreductase), na reira ka kowhiria te whakakore i nga matūkai o nga pūtau puku, me te kaha, me te aukati i te hanga nucleotide me te waikawa amino, e whakaohooho ana i te autophagy, ka mate te pūtau puku me te aukati i te pūtau. whakatipuranga. Ko te Mitochondrial complex I, he mea whakakorikori i roto i nga pūtau mate pukupuku ki te whakatutuki i o raatau hiahia nui mo te kaha, ka whai waahi nui ki te whakatairanga i te tipu o te mate pukupuku.

Whāinga: OXPHOS