Ertugliflozin

Ingoa matū:

(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3 ,4-triol

Waehere SMILES:

"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl "

Waehere InChi:

"InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27 )18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18 -,19-,20+,21-,22-/m0/s1"

Kī InChi:

"MCIACXAZCBVDEE-CUUWFGFTSA-N "

Kupumatua:

Ertugliflozin, PF 04971729,MK-8835,1210344-57-2

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko Ertugliflozin, e mohiotia ana ano ko PF-04971729, he aukati kaha me te whiriwhiri mo te konutai-whakaaro glucose cotransporter 2 me te kaitono haumanu mo te maimoatanga o te mate huka momo 2. Ko nga rangahau haumanu i whakaatu ko Ertugliflozin (1-25 mg / ra) te whakapai ake i te mana glycemic, te taumaha tinana me te pehanga toto i roto i nga turoro me te T2DM i raro i te whakahaere i runga i te metformin, a he pai te manawanui.

Whāinga: SGLT-2